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By targeting different points in the same growth-factor pathway, the kinase inhibitor drugs dabrafenib and trametinib postponed the development of drug resistance in patients with BRAF-positive metastatic melanoma, the study authors said.

Melanoma is the most serious, and often deadly, form of skin cancer. In about half of patients with melanoma that has spread, tumor growth is caused by genetic mutations that keep the BRAF protein -- part of the MAPK cell growth pathway -- constantly activated.

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Drugs that inhibit BRAF activity can rapidly stop and reverse tumor growth in about 90 percent of patients. But the response is temporary in most cases, and tumor growth resumes in six or seven months, the researchers explained. The phase 1 and 2 study was sponsored by GlaxoSmithKline, which developed both drugs.

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In fact, the combination was at least twice as effective as BRAF inhibition alone," he said. One expert agreed that the results were encouraging. These drugs can be safely combined, and the survival was significantly improved without untoward side effects," said Dr. The study was conducted at 14 sites in the United States and Australia and included patients who received different dose combinations of the drugs: two daily milligram mg doses of dabrafenib plus one 2 dermatologist recommended skin care products for aging skin australia dose of trametinib; the same dabrafenib dose with a 1 mg dose of trametinib; or treatment with dabrafenib alone.

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Patients who received dabrafenib alone were able to receive the full-dose combination treatment if their cancer resumed progression. Treatment with both combinations of dabrafenib and trametinib led to a four-month longer delay in drug resistance than treatment with dabrafenib alone. After one year of treatment, 41 percent of patients receiving the full-dose combination treatment had no progression of their melanoma, compared with 9 percent of those receiving dabrafenib alone.

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Among patients receiving the combination treatment, the development of side effects such as skin rash and a less dangerous type of skin cancer called squamous cell carcinoma was similar to that typically seen in patients taking only one of the drugs. The drug combination is now being tested in a larger phase 3 study, which is required for U. Food and Drug Administration approval.

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More information The American Cancer Society has more about melanoma.